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Description
Product Name: Medroxyprogesterone Acetate
Synonyms:medroxyprogesterone 17-acetate; hydroxymethylprogesterone acetate; 17alpha-acetoxy-6-alpha-methylpregn-4-ene-3,20-dione; 17a-hydroxy-6a-methyl-4-pregnene-3,20-dione acetate; depo-provera; (6-alpha)-17-(acetyloxy)-6-methylpreg-4-ene-3,20-dione; 17-(acetyloxy)-6-methyl-(6-alpha)-pregn-4-ene-20-dione; 17-(acetyloxy)-6-methyl-20-dion(6alpha)-pregn-4-ene-; 17-acetoxy-6-alpha-methylprogesterone; 17-alpha-hydroxy-6-alpha-methylpregn-4-ene-3,20-dioneacetate; 17-alpha-hydroxy-6-alpha-methyl-progesteronacetate; 17-alpha-hydroxy-6-alpha-methylprogesteroneacetate; 17-hydroxy-6-alpha-methylpregn-4-ene-3,20-dioneacetate; (17-acetyl-6,10,13-trimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-16-yl) acetate
CAS RN.:71-58-9
EINECS: 200-757-9
Molecular Weight: 386.5244
Molecular Formula: C24H34O4
Density: 1.13g/cm3
Melting Point(°C): 206-207°C
Boiling Point(°C): 500.3°C at 760 mmHg
Flash Point(°C): 215°C
refractive_index: 1.53
| ITEMS | SPECIFICATION | RESULTS |
| Character | White or almost white crystalline powder | Almost White crystalline powder |
| Specific optical rotation | +47°to +53° | +48.2° |
| Impurity F | Not more than 0.5% | <0.5% |
| Identification | Complies by IR | Conforms |
| Related substances | Impurity A not more than 0.3% | Undetected |
| Impurity B not more than 0.7% | Undetected | |
| Impurity C not more than 0.2% | Undetected | |
| Impurity D not more than 1.0% | 0.36% | |
| Impurity E not more than 0.2% | Undetected | |
| Impurity G not more than 0.2% | Undetected | |
| Impurity H not more than0.10% | 0.08% | |
| Impurity I not more than 0.2% | Undetected | |
| Unknown impurity not more than 0.10% | 0.05% | |
| Total impurity not more than 1.5% | 0.49% | |
| Loss on drying | Not more than 1.0% | 0.20% |
| Methylene chloride | Not more than 300ppm | 84ppm |
| Methanol | Not more than 2000ppm | 116ppm |
| Assay | Contains 97.0% to 103.0% of C24H34O4 | 99.80% |
| Calculated on dried basis | ||
| Conclusion | The goods conforms to EP6.0 | |
Function
Angong progesterone is a synthetic luteinizing hormone. The raw material is white or off-white crystalline powder. It is easily soluble in chloroform, dissolved in acetone, slightly soluble in ethyl acetate, slightly soluble in absolute ethanol, insoluble in water. It can quickly repair the endometrium. After the drug is stopped for a period of time, retreating bleeding can occur because the endometrial layer completely falls off and a small amount of residual tissue in the uterus is taken out together. The effect of drug-induced curettage can replace the uterine curettage, and the anti-infective treatment can reduce the complications of medical abortion. It can also be widely used to treat irregular menstruation, dysmenorrhea, etc. Injection can be used as a long-acting contraceptive, large doses for the treatment of breast cancer,
